Borstein also had lead roles as various characters on the sketch comedy series MADtv (1997–2009), as well as Dawn Forchette in the medical comedy series Getting On (2013–2015). She had supporting roles in numerous films, including The Lizzie McGuire Movie (2003), Catwoman (2004), Good Night, and Good Luck (2005), Dinner for Schmucks (2010), Ted (2012), ParaNorman (2012), and A Million Ways to Die in the West (2014)