Outside of film, Sciorra has played recurring roles on Law & Order: Criminal Intent (2005–2006), ER, The L Word (both 2007), CSI (2013), GLOW, Daredevil, Luke Cage (all 2018), Truth Be Told (2019–2020), New Amsterdam, Godfather of Harlem (both 2021), and Blue Bloods (2021–2022). She also starred as Kim Vicidomini in the CBS series Queens Supreme (2003) and as Nora Skoff in Fox's Mental (2009), and was nominated for the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series for portraying Gloria Trillo on The Sopranos (2001–2004)
Her stage credits include The Motherfucker with the Hat (Broadway, 2011), for which she received a Theatre World Award.