Benaderet was then a prominent figure on television in situation comedies, first with The George Burns and Gracie Allen Show from 1950 to 1958, for which she earned two Emmy Award nominations for Best Supporting Actress. In the 1960s, she had regular roles in four series up until her death from lung cancer in 1968, including the commercial successes The Beverly Hillbillies, The Flintstones, and her best known role as Kate Bradley in Petticoat Junction