Ganzel is probably known best as a recurring cast member of The Tonight Show Starring Johnny Carson in the role of the Matinee Lady in the popular Tea Time Movie skits. She has often played stereotypical ditzy blonde bimbo roles, including as Greedy Gretchen in the Three's Company episode Lies My Roommate Told Me (1981), National Lampoon's Movie Madness (1982), the film The Toy (1982) with Jackie Gleason and Richard Pryor, and the Married.